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Prevent concomitant usage of tucatinib with CYP3A substrates, wherever small concentration improvements may cause major or daily life-threatening toxicities. If unavoidable, decrease CYP3A substrate dose In line with solution labeling.Effect of coadministration of a dual CYP3A4 and CYP2C19 inhibitor with fedratinib hasn't been analyzed.modafinil wi